Sequence
3145522 is from the genome.
The highlighted portions of sequence are where there is 75% agreement between all disorder pedictors.
>3145522
MEKLHQCYWKSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML
View in source genome browser
UniProt Gene descriptions
| UniProt |
Gene Name |
Gene Description |
| G1QLH8 |
UBE3A |
Uncharacterized protein |
| G3QMY2 |
UBE3A |
Uncharacterized protein |
| H2Q918 |
ENSG00000114062 |
Uncharacterized protein |
| Q05086 |
UBE3A |
Renal carcinoma antigen NY-REN-54 |
Disordered Regions
75% of predictor's agree:
| Start |
End |
| 19 |
22 |
| 94 |
96 |
| 177 |
203 |
| 207 |
227 |
| 389 |
410 |
| 412 |
413 |
| 416 |
416 |
| 418 |
426 |
By predictor:
| Predictor |
Start |
End |
| VLXT |
1 |
2 |
| VSL2b |
1 |
7 |
| PrDOS |
1 |
28 |
| PV2 |
1 |
33 |
| IUPred-S |
1 |
9 |
| Espritz-N |
1 |
6 |
| Espritz-X |
1 |
5 |
| VSL2b |
9 |
26 |
| Espritz-N |
9 |
22 |
| Espritz-X |
10 |
15 |
| VLXT |
14 |
31 |
| IUPred-L |
19 |
24 |
| IUPred-S |
20 |
22 |
| PrDOS |
55 |
128 |
| VSL2b |
79 |
117 |
| PV2 |
84 |
88 |
| Espritz-N |
84 |
110 |
| PV2 |
90 |
91 |
| Espritz-X |
92 |
96 |
| PV2 |
93 |
117 |
| IUPred-S |
93 |
98 |
| IUPred-L |
93 |
97 |
| IUPred-L |
107 |
108 |
| IUPred-S |
108 |
108 |
| Espritz-N |
113 |
115 |
| Espritz-N |
140 |
161 |
| Espritz-X |
158 |
234 |
| VSL2b |
164 |
230 |
| PV2 |
167 |
236 |
| PrDOS |
169 |
231 |
| Espritz-N |
170 |
237 |
| IUPred-L |
175 |
202 |
| VLXT |
177 |
182 |
| IUPred-S |
178 |
226 |
| VLXT |
193 |
228 |
| IUPred-L |
207 |
226 |
| VLXT |
296 |
300 |
| VSL2b |
298 |
299 |
| VLXT |
324 |
332 |
| Espritz-N |
384 |
404 |
| PrDOS |
385 |
432 |
| Espritz-X |
387 |
425 |
| VSL2b |
388 |
448 |
| PV2 |
388 |
448 |
| VLXT |
389 |
453 |
| IUPred-S |
389 |
425 |
| IUPred-L |
389 |
410 |
| IUPred-L |
412 |
413 |
| Espritz-N |
415 |
427 |
| IUPred-L |
416 |
416 |
| IUPred-L |
418 |
427 |
| PrDOS |
507 |
519 |
| VLXT |
529 |
533 |
| VLXT |
542 |
546 |
| VSL2b |
561 |
569 |
| Espritz-N |
562 |
569 |
| PV2 |
565 |
567 |
| VLXT |
568 |
575 |
| PV2 |
609 |
609 |
| PV2 |
616 |
618 |
| PV2 |
628 |
628 |
| VSL2b |
645 |
651 |
| VSL2b |
698 |
698 |
| Espritz-N |
699 |
702 |
| VSL2b |
700 |
700 |
| VSL2b |
702 |
704 |
| PV2 |
702 |
704 |
| VLXT |
748 |
753 |
| VLXT |
762 |
767 |
| VSL2b |
774 |
778 |
| PV2 |
814 |
814 |
| PV2 |
816 |
816 |
| VLXT |
822 |
823 |
| PV2 |
831 |
831 |
| Espritz-N |
831 |
835 |
| VSL2b |
833 |
836 |
| PV2 |
833 |
836 |
| PV2 |
838 |
843 |
| PV2 |
849 |
850 |
| VSL2b |
853 |
860 |
| PV2 |
853 |
860 |
| PrDOS |
870 |
873 |
| VSL2b |
872 |
875 |
| PV2 |
872 |
875 |
| Espritz-N |
872 |
875 |
| PrDOS |
874 |
875 |
| IUPred-S |
874 |
875 |
SCOP Domain Regions
Hits with strong support:
| Superfamily Name |
SFam ID |
SFam E-value |
Family Name |
Fam ID |
Fam E-value |
Region |
| Hect, E3 ligase catalytic domain |
56204 |
1.44e-120 |
Hect, E3 ligase catalytic domain |
56205 |
0.00000000000219 |
521-868 |
Hits with weaker support:
No weak SCOP hits found.
Pfam Domain Regions
| Type |
Clan |
Family |
Name |
Description |
E-value |
Bitscore |
Start |
End |
| Pfam-B |
No Clan |
PB011726 |
|
|
0.000000000000001 |
58.2 |
54 |
119 |
| Pfam-B |
No Clan |
PB004354 |
|
|
3.1e-64 |
214.7 |
361 |
482 |
| Pfam-B |
No Clan |
PB018304 |
|
|
1.6e-19 |
71.1 |
442 |
575 |
| Pfam-B |
No Clan |
PB019736 |
|
|
0.000000001 |
38.7 |
511 |
599 |
| Pfam-B |
No Clan |
PB004838 |
|
|
0.0000018 |
27.6 |
552 |
593 |
| Domain |
CL0552 |
PF00632.20 |
HECT |
HECT-domain (ubiquitin-transferase) |
1.6e-93 |
313.3 |
576 |
875 |
Post Translational Modification Sites
| Locus |
Amino Acid |
Disordered |
PTM Type |
Sequence Context |
| 30 |
K |
Yes |
UBIQUITYLATION |
RMKRAAAkHLIERYY |
| 71 |
K |
Yes |
UBIQUITYLATION |
DNNAAAIkALELYkI |
| 77 |
K |
Yes |
UBIQUITYLATION |
IkALELYkINAKLCD |
| 90 |
K |
Yes |
UBIQUITYLATION |
CDPHPSKkGASSAyL |
| 96 |
Y |
Yes |
PHOSPHORYLATION |
KkGASSAyLENskGA |
| 100 |
S |
Yes |
PHOSPHORYLATION |
SSAyLENskGAPNNS |
| 101 |
K |
Yes |
UBIQUITYLATION |
SAyLENskGAPNNSC |
| 123 |
K |
Yes |
UBIQUITYLATION |
KGARIDFkDVTyLTE |
| 127 |
Y |
Yes |
PHOSPHORYLATION |
IDFkDVTyLTEEkVY |
| 132 |
K |
No |
UBIQUITYLATION |
VTyLTEEkVYEILEL |
| 158 |
S |
Yes |
PHOSPHORYLATION |
RVIGRVFssAEALVQ |
| 159 |
S |
Yes |
PHOSPHORYLATION |
VIGRVFssAEALVQS |
| 184 |
K |
Yes |
UBIQUITYLATION |
ELKSLQAkDEDKDED |
| 199 |
S |
Yes |
PHOSPHORYLATION |
EKEKAACsAAAMEED |
| 217 |
S |
Yes |
PHOSPHORYLATION |
SSSRIGDssQGDNNL |
| 218 |
S |
Yes |
PHOSPHORYLATION |
SSRIGDssQGDNNLQ |
| 226 |
K |
Yes |
UBIQUITYLATION |
QGDNNLQkLGPDDVS |
| 294 |
R |
No |
MONO-METHYLATION |
FIIVMENrNLHSPEY |
| 311 |
K |
No |
UBIQUITYLATION |
MALPLFCkAMSKLPL |
| 323 |
K |
No |
UBIQUITYLATION |
LPLAAQGkLIRLWSk |
| 330 |
K |
Yes |
UBIQUITYLATION |
kLIRLWSkYNADQIR |
| 342 |
T |
No |
PHOSPHORYLATION |
QIRRMMEtFQQLITy |
| 349 |
Y |
No |
PHOSPHORYLATION |
tFQQLITykVISNEF |
| 350 |
K |
No |
UBIQUITYLATION |
FQQLITykVISNEFN |
| 373 |
K |
No |
UBIQUITYLATION |
DAIVAASkCLKMVYY |
| 421 |
K |
Yes |
UBIQUITYLATION |
GEERRNKkGPRVDPL |
| 465 |
T |
No |
PHOSPHORYLATION |
LEMDKDYtFFkVEtE |
| 468 |
K |
No |
UBIQUITYLATION |
DKDYtFFkVEtENKF |
| 471 |
T |
No |
PHOSPHORYLATION |
YtFFkVEtENKFSFM |
| 479 |
T |
No |
PHOSPHORYLATION |
ENKFSFMtCPFILNA |
| 511 |
Y |
Yes |
PHOSPHORYLATION |
ERRITVLysLVQGQQ |
| 512 |
S |
Yes |
PHOSPHORYLATION |
RRITVLysLVQGQQL |
| 552 |
K |
No |
UBIQUITYLATION |
MENPADLkkQLYVEF |
| 553 |
K |
No |
UBIQUITYLATION |
ENPADLkkQLYVEFE |
| 711 |
K |
No |
UBIQUITYLATION |
PITNENRkEFVNLYS |
| 720 |
Y |
No |
PHOSPHORYLATION |
FVNLYSDyILNkSVE |
| 724 |
K |
No |
UBIQUITYLATION |
YSDyILNkSVEkQFK |
| 728 |
K |
No |
UBIQUITYLATION |
ILNkSVEkQFKAFRR |
| 802 |
K |
No |
UBIQUITYLATION |
HSFTDEQkRLFLQFT |
| 829 |
K |
Yes |
UBIQUITYLATION |
KLKMIIAkNGPDTER |
| 870 |
K |
Yes |
UBIQUITYLATION |
LKAITYAkGFGML__ |