Cryptosporidium hominis
Eukaryota; Alveolata; Apicomplexa; Coccidia; Eimeriida; Cryptosporidiidae; Cryptosporidium
Cryptosporidium hominis, along with Cryptosporidium parvum, is among the medically important Cryptosporidium species. It is an obligate parasite of humans that can colonize the gastrointestinal tract resulting in the gastroenteritis and diarrhea characteristic of cryptosporidiosis. Unlike C. parvum, which has a rather broad host range, C. hominis is almost exclusively a parasite of humans. As a result, C. hominis has a low zoonotic potential compared to C. parvum. It is spread through the fecal-oral route usually by drinking water contaminated with oocyst laden feces. There are many exposure risks that people can encounter in affected areas of the world. Cryptosporidium infections are large contributors of child death and illness in heavily affected areas, yet low importance has been placed on both identifying the species and finding more treatment options outside of nitazoxanide for children and AIDS patients.
Sequence Statistics
| No Sequences | 3934 |
|---|---|
| No Amino Acids | 1769617 |
| Min Seq. Length | 10 |
| Avg. Seq. Length | 449.826 |
| Max Seq. Length | 4726 |
| Seq. Length 1σ | 394.774 |
Disorder Prediction Statistics
| Predictor | % Genome Disordered | % Genome Disordered in SCOP Domains | Avg. % of Seq. Disordered | Avg. % of Disordered Regions in SCOP Domains | Avg. % of Seq. Disordered and in SCOP Domains |
|---|---|---|---|---|---|
| VLXT | 23.826 | 3.640 | 24.407 | 19.748 | 4.147 |
| VSL2b | 37.757 | 4.184 | 38.647 | 16.827 | 4.796 |
| PrDOS | 36.623 | 3.846 | 37.987 | 14.416 | 4.248 |
| PV2 | 35.415 | 4.207 | 39.399 | 17.151 | 4.957 |
| IUPred-S | 12.757 | 0.572 | 13.963 | 7.956 | 0.862 |
| IUPred-L | 14.022 | 0.586 | 17.958 | 11.029 | 1.013 |
| Espritz-N | 22.142 | 2.087 | 21.599 | 14.686 | 2.279 |
| Espritz-X | 13.522 | 0.572 | 15.443 | 7.761 | 0.911 |
| Espritz-D | 4.772 | 0.389 | 38.129 | 8.799 | 5.554 |
SUPERFAMILY Domains
| % Amino Acids with SCOP Assignment | % Sequences with SCOP Assignment | No of Domains | No of Superfamilies | No of Families | Avg. Family Size | Avg. Domain Length | Domain Pairs | Unique Domain Architectures |
|---|---|---|---|---|---|---|---|---|
| 29 | 46 | 2586 | 503 | 236 | 5.1 | 450 | 276 | 969 |