Cryptosporidium hominis, along with Cryptosporidium parvum, is among the medically important Cryptosporidium species. It is an obligate parasite of humans that can colonize the gastrointestinal tract resulting in the gastroenteritis and diarrhea characteristic of cryptosporidiosis. Unlike C. parvum, which has a rather broad host range, C. hominis is almost exclusively a parasite of humans. As a result, C. hominis has a low zoonotic potential compared to C. parvum. It is spread through the fecal-oral route usually by drinking water contaminated with oocyst laden feces. There are many exposure risks that people can encounter in affected areas of the world. Cryptosporidium infections are large contributors of child death and illness in heavily affected areas, yet low importance has been placed on both identifying the species and finding more treatment options outside of nitazoxanide for children and AIDS patients.

Sequence Statistics

No Sequences3934
No Amino Acids1769617
Min Seq. Length10
Avg. Seq. Length449.826
Max Seq. Length4726
Seq. Length 1σ394.774

Disorder Prediction Statistics

Predictor % Genome Disordered % Genome Disordered in SCOP Domains Avg. % of Seq. Disordered Avg. % of Disordered Regions in SCOP Domains Avg. % of Seq. Disordered and in SCOP Domains
VLXT 23.826 3.640 24.407 19.748 4.147
VSL2b 37.757 4.184 38.647 16.827 4.796
PrDOS 36.623 3.846 37.987 14.416 4.248
PV2 35.415 4.207 39.399 17.151 4.957
IUPred-S 12.757 0.572 13.963 7.956 0.862
IUPred-L 14.022 0.586 17.958 11.029 1.013
Espritz-N 22.142 2.087 21.599 14.686 2.279
Espritz-X 13.522 0.572 15.443 7.761 0.911
Espritz-D 4.772 0.389 38.129 8.799 5.554

SUPERFAMILY Domains

% Amino Acids with SCOP Assignment % Sequences with SCOP Assignment No of Domains No of Superfamilies No of Families Avg. Family Size Avg. Domain Length Domain Pairs Unique Domain Architectures
29 46 2586 503 236 5.1 450 276 969

Discussion about Cryptosporidium hominis


comments powered by Disqus