Candida parapsilosis is a fungal species of the yeast family that has become a significant cause of sepsis and of wound and tissue infections in immuno-compromised patients. The immune system is a major player in Candida parapsilosis infections. Unlike Candida albicans and Candida tropicalis, Candida parapsilosis is not an obligate human pathogen, having been isolated from nonhuman sources such as domestic animals, insects or soil. Candida parapsilosis is also a normal human commensal and it is one of the fungi most frequently isolated from the human hands. There are several risk factors which can help Candida parapsilosis to colonize human host. Immuno-compromised individuals and surgical patients, particularly those having surgery of the gastrointestinal tract are at high risk for infection with Candida parapsilosis. There is currently no consensus on the treatment of invasive candidiasis caused by Candida parapsilosis, although the therapeutic approach typically includes the extraction of any removable foreign bodies and the administration of a systemic antifungal. Historically, Amphotericin B has been the most frequently used anti fungal. Fluconazole is a frequently administrated alternative to Amphotericin B.

Sequence Statistics

No Sequences5733
No Amino Acids2924508
Min Seq. Length43
Avg. Seq. Length510.118
Max Seq. Length4128
Seq. Length 1σ349.502

Disorder Prediction Statistics

Predictor % Genome Disordered % Genome Disordered in SCOP Domains Avg. % of Seq. Disordered Avg. % of Disordered Regions in SCOP Domains Avg. % of Seq. Disordered and in SCOP Domains
VLXT 29.147 5.631 28.807 27.445 6.246
VSL2b 39.344 6.104 39.044 24.769 6.951
PrDOS 39.256 4.590 38.463 19.439 5.050
PV2 42.860 7.340 43.303 25.497 8.140
IUPred-S 20.446 1.215 19.870 13.186 1.558
IUPred-L 22.813 1.467 23.619 19.196 1.943
Espritz-N 29.537 3.726 28.076 22.304 3.994
Espritz-X 21.448 1.079 21.268 10.312 1.450
Espritz-D 7.540 0.359 22.393 7.083 3.007

SUPERFAMILY Domains

% Amino Acids with SCOP Assignment % Sequences with SCOP Assignment No of Domains No of Superfamilies No of Families Avg. Family Size Avg. Domain Length Domain Pairs Unique Domain Architectures
39 63 5170 769 583 6.7 510 521 1623

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