Humans (Homo sapiens, meaning "thinking man" or "wise man") are the most common and widespread species of primate, and the only extant species of the genus Homo. They are great apes characterized by hairlessness, obligate bipedality, manual dexterity with opposable thumbs, precision grip, and high intelligence. Humans have large brains compared to body size (a high encephalization quotient), enabling more advanced cognitive skills that facilitate successful adaptation to varied environments, development of sophisticated tools, and formation of complex social structures and civilizations. Humans possess a disproportionately larger volume of both cerebral white matter and gray matter present in the prefrontal cortex (PFC) than any other primate species, which facilitated the expansion of higher-order executive functions.

Sequence Statistics

Disorder Prediction Statistics

Predictor	% Genome Disordered	% Genome Disordered in SCOP Domains	Avg. % of Seq. Disordered	Avg. % of Disordered Regions in SCOP Domains	Avg. % of Seq. Disordered and in SCOP Domains
VLXT	36.806	7.699	36.184	27.481	7.641
VSL2b	46.094	8.759	45.337	25.926	8.724
PrDOS	40.315	5.475	44.027	20.160	6.075
PV2	49.673	10.747	52.813	26.915	11.132
IUPred-S	23.492	1.969	24.291	15.204	2.269
IUPred-L	26.832	2.539	28.966	19.564	2.903
Espritz-N	34.685	5.292	32.935	21.901	4.862
Espritz-X	22.928	1.501	25.486	12.538	2.036
Espritz-D	11.415	0.956	44.851	11.191	6.929

% Amino Acids with SCOP Assignment	% Sequences with SCOP Assignment	N^o of Domains	N^o of Superfamilies	N^o of Families	Avg. Family Size	Avg. Domain Length	Domain Pairs	Unique Domain Architectures
44	61	115355	1113	1380	103.6	373	1689	7644